Zmiany w szlakach przekazywania sygnału

Mutations within genes coding for G protein-coupled receptors (GPCRs) can lead to one of two major outcomes—a loss-of-function or a gain-of-function. Loss-of-function mutations prevent signaling in GPCR pathways, even in the presence of signaling molecules. Gain-of-function mutations activate signaling in GPCR pathways, even in the absence of signaling molecules.

Which of the following is most likely to result from a loss-of-function GPCR mutation?

(Choice A)
Signal transduction pathways that are inactive even if ligand-to-receptor binding occurs
(Choice B)
Signal transduction pathways that are activated by multiple types of ligands
(Choice C)
Signal transduction pathways that are inactive only if ligand-to-receptor binding does not occur
(Choice D)
Signal transduction pathways that are activated without ligand-to-receptor binding

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Biologia - program rozszerzony

Kurs: Biologia - program rozszerzony > Rozdział 4

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