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Adenoviruses are a family of highly contagious viruses that most commonly cause illnesses of the respiratory system, such as bronchitis or pneumonia. In the first phase of an adenovirus infection, the host cell expresses several viral proteins. One of these proteins, E1B-55k, inhibits the activity of the host protein p53, a tumor suppressor that arrests the cell cycle or induces apoptosis when DNA damage is detected.
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